The Role of Losartan in the Prevention of Early Structural Changes Associated With Radiation-Induced Heart Failure
Status: Recruiting
Location: See location...
Intervention Type: Drug, Radiation
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer. The interventions involved in this study are: * Losartan * Radiation Therapy (standard of care)
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
• \>18 years of age
⁃ Non-metastatic Breast Cancer patients who are scheduled to receive conventional left breast/chest wall RT inclusive of treatment to the internal mammary lymph nodes (IMNs)
⁃ Prior chemotherapy is permitted
⁃ Patients must have Left-sided Breast Cancer
⁃ Ability to understand and the willingness to sign a written informed consent document
⁃ No contraindication to MRI
Locations
United States
Massachusetts
Massachusetts General Hospital Cancer Center
RECRUITING
Boston
Contact Information
Primary
Rachel Jimenez, MD
rbjimenez@partners.org
617-726-8651
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2024-12-01
Participants
Target number of participants: 10
Treatments
Experimental: Radiation Therapy and Losartan
Participants will receive radiation therapy 5x weekly over 1-6 weeks. Participants will receive Losartan 1x daily during radiation therapy and for up to 6 months afterward then be followed for 1 year
Related Therapeutic Areas
Sponsors
Leads: Massachusetts General Hospital